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Testosterone, Dihydrotestosterone (DHT), Androstenedione, Dehydroepiandrosterone (DHEA), Androsterone, Etiocholanolone

Estradiol, Estrone, Estriol, Progesterone, 17-Hydroxyprogesterone, Allopregnanolone, Pregnenolone,  17-Hydroxypregnenolone 

Cortisol, Cortisone, 11-Deoxycortisol, 21-Deoxycortisol, Corticosterone, 11-Deoxycorticosterone (DOC), Aldosterone, Androstenedione, 17-Hydroxyprogesterone, Epinephrine, Norepinephrine, Dopamine,  Normetanephrine, 3-Methoxytyramine, Vanillylmandelic acid (VMA) 

rT3, IGF-1

LC-MS/MS is used on dried blood spot extracts to simultaneously quantify classes of metabolites including amino acids and acylcarnitines, as well as certain steroids and other small molecules 

LC/MS/MS quantitatively measures 35+ individual plasma amino acids with high specificity to confirm abnormal newborn-screen results, differentiate true disease from false positives, and guide diagnosis and management of suspected aminoacidopathies.

Liquid–liquid extraction isolates analytes by partitioning them between immiscible aqueous and organic phases, allowing proteins and salts to be left behind before LC-MS/MS analysis. 

Solid-phase extraction retains analytes on a sorbent cartridge so matrix interferences can be washed away and the purified analytes eluted in a clean solvent. 

Supported liquid extraction uses an inert solid support to disperse the aqueous sample and enhance organic solvent extraction efficiency with minimal emulsions 

Protein precipitation removes proteins with plates or by adding an organic solvent (e.g., acetonitrile or methanol), then analyzing the cleared supernatant. 

Dilute-and-shoot simply dilutes the sample with solvent or mobile phase to reduce matrix effects, enabling direct injection into the LC-MS/MS system 

Derivatization chemically modifies analytes to improve chromatographic retention, volatility, or ionization efficiency before LC-MS/MS analysis. 

Phospholipid-removal plates selectively bind phospholipids to reduce matrix effects and ion suppression while preserving target analytes. 

Hamilton, Tecan, Andrew Alliance 

GC-MS to LC-MS conversions. Quad or TOF. 

Traditional and Designer Drugs

Riboflavin (vitamin B2), Nicotinamide (vitamin B3), Pantothenic acid (vitamin B5), Pyridoxal-5-phosphate (vitamin B6), Biotin (vitamin B7), 5-Methyltetrahydrofolate (vitamin B9), Total cobalamin (vitamin B12), Ascorbic acid (vitamin C) 

Retinol (vitamin A), 25-Hydroxyvitamin D2, 25-Hydroxyvitamin D3, Alpha-tocopherol (vitamin E), Phylloquinone (vitamin K1), Menaquinone-4 (vitamin K2), Coenzyme Q10 (total) 

 Glutaric acid, 3-Hydroxyglutaric acid, Ethylmalonic acid, Methylmalonic acid, Malonic acid, 3-Hydroxypropionic acid, 3-Methylglutaric acid, 3-Methylglutaconic acid, Adipic acid, Suberic acid, Sebacic acid, Tiglylglycine, Isovalerylglycine, Propionylglycine, Orotic acid, Oxalic acid, Hippuric acid, Benzoic acid, Vanillylmandelic acid (VMA), Homovanillic acid (HVA), 5-HIAA, Citric acid, Isocitric acid, cis-Aconitic acid, α-Ketoglutaric acid, Succinic acid, Fumaric acid, Malic Acid

 Lactic acid, Pyruvic acid, 3-Hydroxybutyric acid (β-hydroxybutyrate), Acetoacetic acid, 2-Hydroxybutyric acid, Methylmalonic acid, Uric acid 

Lithium (Li), Beryllium (Be), Aluminum (Al), Vanadium (V), Chromium (Cr), Manganese (Mn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Zinc (Zn), Gallium (Ga), Arsenic (As), Selenium (Se), Rubidium (Rb), Strontium (Sr), Molybdenum (Mo), Cadmium (Cd), Indium (In), Tin (Sn), Antimony (Sb), Tellurium (Te), Barium (Ba), Tungsten (W), Thallium (Tl), Lead (Pb), Bismuth (Bi), Uranium (U) 

Lithium (Li), Beryllium (Be), Aluminum (Al), Vanadium (V), Chromium (Cr), Manganese (Mn), Cobalt (Co), Nickel (Ni), Copper (Cu), Zinc (Zn), Gallium (Ga), Arsenic (total), Monomethylarsonic acid (MMA), Dimethylarsinic acid (DMA), Selenium (Se), Rubidium (Rb), Strontium (Sr), Molybdenum (Mo), Cadmium (Cd), Indium (In), Tin (Sn), Antimony (Sb), Tellurium (Te), Barium (Ba), Tungsten (W), Thallium (Tl), Lead (Pb), Bismuth (Bi), Uranium (U), Cesium (Cs) 

Lithium (Li), Aluminum (Al), Chromium (Cr), Manganese (Mn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Zinc (Zn), Arsenic (As), Selenium (Se), Rubidium (Rb), Strontium (Sr), Molybdenum (Mo), Tin (Sn), Antimony (Sb), Barium (Ba) 

Lithium (Li), Aluminum (Al), Vanadium (V), Chromium (Cr), Manganese (Mn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Zinc (Zn), Gallium (Ga), Selenium (Se), Rubidium (Rb), Strontium (Sr), Molybdenum (Mo), Tin (Sn), Antimony (Sb), Barium (Ba)